|
Overview
| Day 1
| Day 2
| Day 3
| Download
Brochure | Breakout
Discussions
Pre-Conference Short Courses
Tuesday, February 24
| Recommended Short Courses*
|
9:00am-12:00pm
(SC5) Fragment-Inspired Medicinal Chemistry (Click
on the title to view the full
description)
|
|
Fragment-based drug discovery has
generated a wealth of papers over the
last decade, but how effective is it for
actually generating lead series? In this
short course, you will learn practical
approaches for applying fragment-based
methods to medicinal chemistry.
-
Fragment-Based Approaches as
Platforms for Medicinal Chemistry
-
Fragment-Based Methods that Inspire
Fresh Approaches to Lead Generation
-
Optimization of Fragment Hits
-
Combining Technology with
Fragment-Based Methods to Advance
Medicinal Chemistry
-
Facing the Challenge of Applying
Fragment-Based Approaches When
Structural Information is not
Available
Course Instructors:
Daniel A. Erlanson, Ph.D.,
Cofounder, Carmot Therapeutics, Inc.
Edward R. Zartler, Ph.D., Research
Fellow, Bioprocess & Bioanalytical
Research, Merck & Co.
James Murray, Ph.D., Director of
Structural Sciences, Vernalis
Hans-Dieter Junker, Ph.D., Head of
Chemistry, Graffinity
Pharmaceuticals GmbH
*Separate Registration Required
|
*Separate Registration Required |
Topics to be covered:
-
Fragment-Based Approaches as
Platforms for Medicinal Chemistry
-
Fragment-Based Methods that Inspire
Fresh
-
Approaches to Lead Generation
-
Optimization of Fragment Hits
-
Combining Technology with Fragment-Based
Methods to Advance Medicinal Chemistry
Facing the Challenge of Applying Fragment-Based Approaches
When Structural Information is not Available
Conference Topics Include
-
Meeting The Challenges in Modern Medicinal
Chemistry I
-
Meeting the Challenges in Modern Medicinal
Chemistry II
-
Fragment-Based Inhibitor Design, Screening
and Optimization
-
FDA Approval Case Study
-
Alzheimer Therapeutics
-
Pain Inhibitor
-
Antiviral and Ant-infective Therapeutics –
HCV and HIV Inhibitors
Plenary Keynote Speakers
 Brave
New Age of Personalized Medicine
David Ewing Duncan, Chief Correspondent, NPR Talk’s “Biotech
Nation” and Best Selling Author
“Masterminds”
 Using
Molecular Medicine to do Therapeutic Development in the Network
Age
Jay M. Tenenbaum, Ph.D., Chairman and Chief Scientist,
CollabRx, Inc.
 Engineering
Cells to Death
James A. Wells, Ph.D., Chair, Department of Pharmaceutical
Chemistry; Professor of Pharmaceutical Sciences, Departments of
Pharmaceutical Chemistry and Cellular & Molecular Pharmacology;
and Director of the Small Molecule Discovery Center, University
of California, San Francisco
Detection, Assignment and Analysis of Multiple Scaffolds for Medicinal Chemistry Project Databases
Alex Clark, Ph.D., Research Scientist, R&D, Chemical Computing Group, Inc. |
Sponsored
by:
|
| Analysis of structure-activity relationships within lead optimization databases requires knowledge of each of the common scaffold substructures, an understanding of how the substitution sites map to each other, and an optimal assignment of scaffolds to input molecules in the event of ambiguity. We will present algorithms for solving each of these problems, which are capable of operating using only the molecules themselves as input, as well as being able to take into account any scaffold hints which may be known beforehand. Also discussed will be methods for depicting the resulting information in a visually intuitive way, as well as compilation of the results in the form of a report which allows structure-activity trends to be examined interactively. |
|
Overview
| Day 1
| Day 2
| Day 3
| Download
Brochure | Breakout
Discussions
For questions or suggestions about
the meeting, please contact:
Edel O'Regan
Cambridge Healthtech Institute
250 First Avenue, Suite #300
Needham, MA 02494
Tel: 781-972-5423
Fax: 781-972-5425
email:
eoregan@healthtech.com
For sales information, contact:
Carol Dinerstein
Tel: 781-972-5471
email:
dinerstein@healthtech.com
OR
Jon Stroup
Tel: 781-972-5483
email:
jstroup@healthtech.com
|
2009 Final
Brochure Download
|
